Paracetamol facilitate the formation of thrombin so as to speedup of maintain the normal concretion time of blood.As well as it facilitate the formation. Paracetamol is also diuretic and strengthen liver's detoxification ability. Deficiency of VK3 will lead to longer concretion time of blood or to bleeding nonstop. That meens even very small wounds may lead to the breach of blood vessels. Resulting in extensive observable under-skin bleeding and bleeding fo other apparatuses or organs sush as: muscles,brain,stomach,intestines,abdomen,urinary systerm,genital system and so on. More seriously. Paracetamol may lead to hematuria and anaemia,even death.
Acetaminophen is produced by the metabolism of phenacetin in the body. Its inhibitory effect on prostaglandin synthesis in the central nervous system is similar to that of aspirin, but its inhibitory effect on peripheral prostaglandin synthesis is weak, so it has strong antipyretic and analgesic effects and weak anti-rheumatic effects. No effect on platelet coagulation mechanism. Oral absorption is rapid, complete, and evenly distributed in body fluids. Most of it is metabolized in the liver. The intermediate metabolites are toxic to the liver and are excreted in the form of glucuronic acid conjugates or from the kidneys. The half-life is generally 1-4 hours.
Product Name
|
Paracetamol
|
English alias
|
4-Acetamido pheno;
|
Appearance
|
White crystalline powder, tasteless, soluble in hot water, ether, chlorofor, etc.
|
Content
|
99%-101%.
|
Quality Standard
|
BP\USP
|
Related categories
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APIs; Western medicines and APIs; Aromatics
|
CAS number
|
103-90-2
|
Molecular formula
|
C8H9NO2
|
Usage
|
Antipyretic and analgesic
|
1) Paracetamol is approved for reducing fever in people of all ages.
2) Paracetamol is used for the relief of pains associated with many parts of the body.while its anti inflammatory effects are weaker.
3) Paracetamol facilitate the formation of thrombin so as to speedup of maintain the normal concretion time of blood.As well as it facilitate the formation.
4) Paracetamol is also diuretic and strengthen liver's detoxification ability.
1.Paracetamole is approved for reducing fever in people of all ages.
2.Paracetamole is used for the relief of pains associated with many parts of the body. It has analgesic properties comparable to those of aspirin,
3.while its anti-inflammatory effects are weaker. It is better tolerated than aspirin in patients in whom excessive gastric acid secretion or prolongation of bleeding time may be a concern.
ITEM | SPECIFICATION | RESULT |
Characteristics | A white crystalline powder | A white crystalline powder |
Solubility | Sparingly soluble in water,freely soluble in alcohol,very slightly soluble in ether | Complies |
Identification | Complies | Complies |
Melting range | 168~172ºC | 169.0~170.0ºC |
Chloride | Not more than 0.014% | <0.014% |
Sulphate | Not more than 0.02% | <0.02% |
Sulfide | No coloration or spotting occurs | Complies |
Readily carbonizable substances | Complies | Complies |
FreeP-aminophenol | Not more than 0.005% | <0.005% |
Related substance | Complies | Complies |
Loss on drying | Not more than 0.5% | 0.08% |
Residue on ignition | Not more than 0.1% | 0.04% |
OVI | Meet the requirements | Complies |
Assay | 99.0~101.0% | 99.4% |
Heavy metals | Not more than 0.001% | <0.001% |
Conclusion | The product meet the testing requirements |
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