What is Artesunate ?
Artesunate is an antimalarial agent. It is a water-soluble hemisuccinate derivative of dihydroartemisinin.
Artemisinin is a sesquiterpene lactone isolated from Artemisia annua, a herb that has traditionally been used in China for the treatment of malaria.
Artesunate and its active metabolite dihydroartemisinin are potent blood schizonticides, active against the ring stage of the parasite. Artesunate is ideal for the treatment of severe malaria, including cerebral malaria. It is also active against chloroquine and mefloquine resistant strains of P. falciparum. It is unstable in neutral solution and is therefore only available for injections as artesunic acid. The injectable formulation must be prepared immediately before use in 5% (w/v) sodium bicarbonate solution to produce the salt sodium artesunate.
Name | Artesunate |
CAS NO. | 88495-63-0 |
Molecular formula | C19H28O8 |
Assay | 99% |
Characteristic | White crystalline powder |
Molecular weight | 384.42 |
1.Artesunate with function of controlling of vivax malaria and falciparum malaria symptom, as well as treatment of chloroquine-resistant strain of insect.
2. Artesunate with function of oxidant. artemisinin is reduced by catalase,dithiothreitol and alpha tocopherol.
3.Artesunate with the function of antibacterial, artemisinin has anti-influenza virus effect.
4.Artesunate with the function of anti-parasite, artemisinin on the role of anti-schistosomiasis and leptospirosis.
ANALYSIS | SPECIFICATION | RESULTS |
Appearance | Off white powder | Complies |
Odor | Characteristic | Complies |
specification | Nobiletin 98% | Complies |
Sieve analysis | 100% pass 80 mesh | Complies |
Loss on Drying | ≤5.0% | Complies |
Residue on Ignition | ≤5.0% | Complies |
Heavy Metal | <10ppm | Complies |
As | ≤1ppm | Complies |
Residual Solvents | EP2000 | Complies |
Residual Pesticide | Negative | Complies |
Microbiology | ||
Total Plate Count | <1000cfu/g | Complies |
Yeast & Mold | <100cfu/g | Complies |
E.Coli | Negative | Complies |
Salmonella | Negative | Complies |
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