Supply Food Grade Nutrition Supplements Alpha-Ketoglutaric acid/2-Ketoglutaric acid

1.alpha ketoglutaric acid  used as tricarboxylic acid cycle

α- Ketoglutarate is an important metabolic intermediate in the microbial tricarboxylic acid cycle, which is a key node connecting the carbon nitrogen metabolism in cells. It is located after isocitric acid and before succinyl coenzyme A in the cycle. In this part, anaplerotic reaction can be generated through Transamination of glutamic acid α- The purpose of supplementing this intermediate metabolite with ketoglutaric acid can also be achieved through the action of glutamate dehydrogenase on glutamate.

2. alpha-ketoglutaric acid used for Generate amino acids

Glutamic acid can generate glutamine under the action of glutamine synthase, which uses a molecule of ATP to produce glutamine phosphate; This intermediate product is attacked by ammonia as a nucleophilic reagent, resulting in the formation of glutamine and inorganic phosphate.
3. alpha ketoglutaric acid used for dietary supplements
α- Ketoglutaric acid is sold as a dietary supplement under the trade name AKG or a-KG and is sold to fitness enthusiasts or bodybuilders. The seller claims that this substance can improve performance at the peak of training. The seller claims that this is based on "research indicating that excessive ammonia can bind to α- Ketoglutaric acid is taken away to reduce the numerous problems caused by ammonia poisoning. However, it showed that α- The only effective study on ketoglutarate in reducing ammonia poisoning is only for patients who have undergone hemodialysis.